![]() A capsule-in-capsule oral delivery system comprising: The oral delivery system of claim 1, wherein the biodegradable second capsule is band sealed. The oral delivery system of claim 1, wherein the biodegradable first capsule is band sealed. The oral delivery system of claim 1, wherein the biodegradable first capsule and the biodegradable second capsule each comprise hydroxypropylmethyl cellulose. The oral delivery system of claim 1, wherein the first and second biodegradable capsule is fabricated of hydroxypropylmethyl cellulose. ![]() The oral delivery system of claim 4, wherein the probiotic formulation targeted to the proximal colon and the probiotic formulation targeted to the ileum each further comprise Faecalibacterium prausnitzii and/or Bacteroides thetaiotaomicron. The oral delivery system of claim 1, wherein the probiotic formulation targeted to the proximal colon and the probiotic formulation targeted to the ileum each comprise a live bacterial suspension comprising a bacteria selected from the genus Lactobacillus and Bifidobacterium. The oral delivery system claim 1, wherein the probiotic formulation targeted to the proximal colon and the probiotic formulation targeted to the ileum each comprise at least one to 30 species or different strains of bacteria. ![]() The oral delivery system of claim 1, wherein the enteric coating comprises one or more polymers each selected from the group consisting of copolymers of methacrylic acid, and copolymers of methacrylic acid and methyl methacrylate. ![]() An oral delivery system for delivering a probiotic formulation targeted to both the ileum and proximal colon of a subject Ī biodegradable first capsule comprising a probiotic formulation targeted to the proximal colon, wherein the first capsule comprises a reverse enteric coating, wherein the reverse enteric coating solubilizes in a pH of about 6.2 to about 6.5 andĪ biodegradable second capsule that includes the first capsule and a probiotic formulation targeted to the ileum, wherein the second capsule comprises an enteric coating that solubilizes in a pH of about 7 to 8, wherein the second capsule releases the first capsule and the probiotic formulation targeted to the ileum in the ileum upon administration to a patient, and once released, the first capsule is solubilized in the proximal colon of the patient at a pH of about 6.2 to about 6.5 and releases the probiotic formulation targeted to the proximal colon. ![]()
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